Increased femoral neck cancellous bone and connectivity in coxarthrosis (hip osteoarthritis)

Abstract

Patients with coxarthrosis (cOA) have a reduced incidence of intracapsular femoral neck fracture, suggesting that cOA offers protection. The distribution of bone in the femoral neck was compared in cases of coxarthrosis and postmortem controls to assess the possibility that disease-associated changes might contribute to reduced fragility. Whole cross-section femoral neck biopsies were obtained from 17 patients with cOA and 22 age- and sex-matched cadaveric controls. Densitometry was performed using peripheral quantitated computed tomography (pQCT) and histomorphometry on 10-μm plastic-embedded sections. Cortical bone mass was not different between cases and controls ( P > 0.23), but cancellous bone mass was increased by 75% in cOA ( P = 0.014) and histomorphometric cancellous bone area by 71% ( P < 0.0001). This was principally the result of an increase of apparent density (mass/vol) of cancellous bone (+45%, P = 0.001). Whereas cortical porosity was increased in the cases ( P < 0.0001), trabecular width was also increased overall in the cases by 52% ( P < 0.001), as was cancellous connectivity measured by strut analysis ( P < 0.01). Where osteophytic bone was present ( n = 9) there was a positive relationship between the amount of osteophyte and the percentage of cancellous area ( P < 0.05). Since cancellous bone buttresses and stiffens the cortex so reducing the risk of buckling, the increased cancellous bone mass and connectivity seen in cases of cOA probably explain, at least in part, the ability of patients with cOA to resist intracapsular fracture of the femoral neck during a fall.