Abstract
Methods The percentages of MDSCs, IFN-γ-producing CD4 and CD8 T cells in the peripheral blood of HCC patients, chronic hepatitis B (CHB) patients, and healthy controls (HC) were determined by flow cytometry. The serum concentrations of IL-10 and TNF-α were determined by ELISA. The association of the percentages of MDSCs with tumor burden, liver function parameters, systemic inflammation-related indexes, and IFN-γ-producing T cells was assessed. Results The percentages of MDSCs and PMN-MDSCs were significantly higher in HCC patients than those in CHB patients and HC. The level of MDSCs was correlated with indirect bilirubin and prealbumin, as well as systemic inflammation response index, monocyte/lymphocyte ratio, and monocyte counts. The frequency of IFN-γ-producing CD8 T cells of HCC patients was lower than that of HC. However, there was no relationship between MDSCs and IFN-γ-producing CD8 T cells. The level of IL-10 in HCC patients was significantly higher than that in CHB patients. Conclusion MDSCs seem to play an important role in the process leading from chronic HBV infection to HCC. Early inhibiting these cells could affect tumor progression.
Highlights
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the most important cause of death in patients with cirrhosis [1]
The frequency of M-Myeloid-derived suppressor cells (MDSCs) in hepatocellular carcinoma (HCC) patients was significantly increased compared with healthy controls (HC), but there was no significant difference between HCC patients and chronic hepatitis B (CHB) patients
To investigate whether the change in MDSC level was due to the effect of anti-hepatitis B virus (HBV) therapy before HCC occurrence, HCC patients were divided into two groups according to whether they received antiviral therapy, and the percentages of MDSCs and their subsets were analyzed
Summary
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the most important cause of death in patients with cirrhosis [1]. Due to the difference of cell sample types and phenotypic heterogeneity of human MDSCs, the results of these studies were inconsistent and controversial. The percentages of MDSCs, IFN-γ-producing CD4 and CD8 T cells in the peripheral blood of HCC patients, chronic hepatitis B (CHB) patients, and healthy controls (HC) were determined by flow cytometry. The association of the percentages of MDSCs with tumor burden, liver function parameters, systemic inflammation-related indexes, and IFN-γ-producing T cells was assessed. MDSCs seem to play an important role in the process leading from chronic HBV infection to HCC. Inhibiting these cells could affect tumor progression
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