Increased expression of long non-coding RNA CCEPR is associated with poor prognosis and promotes tumorigenesis in urothelial bladder carcinoma.

Yonghao Zhan,Yifan Li,Yuchen Liu,Zhiming Cai,Xuesong Li,Liqun Zhou,Bao Guan,Ding Peng,Yanqing Gong,Anbang He,Zhicong Chen,Shiming He,Xiaoying Chen

doi:10.18632/oncotarget.17872

Yonghao Zhan, Yifan Li + Show 11 more

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https://doi.org/10.18632/oncotarget.17872

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Abstract

Recent emerging evidences have showed that long non-coding RNAs play important regulatory roles in diverse biological processes of tumor development and progression. CCEPR (cervical carcinoma expressed PCNA regulatory lncRNA) is a novel identified lncRNA that acts as a potential biomarker and involves in development and progression of cervical carcinoma. Nevertheless, we know nothing about the clinical significance and molecular mechanism of CCEPR in bladder cancer. In this study, we found that CCEPR was significantly up-regulated in bladder cancer. Furthermore, up-regulated CCEPR expression was positively correlated with advanced TNM stage and higher histological grade. Moreover, further experiments demonstrated that CCEPR promotes cell proliferation and suppresses cell apoptosis in bladder cancer. Mechanistically, we found CCEPR upregulates the expression of PCNA in mRNA and protein level to promote cancer growth. In conclusions, these findings demonstrated that CCEPR plays an important regulatory role in bladder cancer and may serve as a potential diagnostic biomarker and therapeutic target.

Highlights

Urothelial carcinoma of the bladder is one of most common malignancy all over the world and the most common urologic tumors in China [1, 2]
CCEPR is a novel identified lncRNA that acts as a potential biomarker and involves in development and progression of cervical carcinoma
These findings demonstrated that CCEPR plays an important regulatory role in bladder cancer and may serve as a potential diagnostic biomarker and therapeutic target

Summary

Introduction

Urothelial carcinoma of the bladder is one of most common malignancy all over the world and the most common urologic tumors in China [1, 2]. LncRNAs are a class of noncoding RNAs which are greater than 200 nucleotides in length and limited coding potential [15,16,17]. The rapid development of human genomics has highlighted the important role of non-coding RNAs in diverse biological processes of cancer [18,19,20]. Recent emerging evidences have shown that lncRNAs play key roles in development and progression of bladder cancer, such as UCA-1, PVT-1, MALAT1, SPRY4-IT1, PANDAR and etc [21,22,23,24,25,26,27,28,29,30]. CCEPR (cervical carcinoma expressed PCNA regulatory lncRNA, GenBank number AK055418) is a novel identified lncRNA with 2504 nucleotides in length and localized at the chromosome 10 [20]. Its biological function in bladder cancer development is still completely unknown

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