Abstract
The chemotactic activities of eosinophils and neutrophils were measured in bronchial washes obtained from 6 symptom-free patients with previous extrinsic allergic alveolitis and 9 healthy volunteers. An increased chemotactic activity was found in the washes obtained from the patients, and the recovery of eosinophils was correlated with the eosinophil chemotactic activity, suggesting a causal relationship. Chromatography of the fluids obtained suggested that low molecular weight compounds were principally responsible for the increased chemotactic activity. A mild disturbance of the integrity of the alveolocapillary barrier could to some extent add to the explanation of the increased chemotactic activity in the washes obtained from the patients.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have