Increased EMMPRIN Serum Levels in Vascular Dementia Positively Correlate with Matrix Metalloproteinase 2

Abstract

Event Abstract Back to Event Increased EMMPRIN Serum Levels in Vascular Dementia Positively Correlate with Matrix Metalloproteinase 2 Yuek Ling Chai1*, Christopher P Chen1, Edward HM Koo1 and Mitchell KP Lai1 1 National University of Singapore, Singapore Background Vascular dementia (VaD) is primarily attributed to stroke or cerebrovascular disease, and is characterized by changes in blood vessels and surrounding extracellular matrix (ECM) in the brain. Matrix metalloproteinases (MMPs) play an important role in vascular remodeling. However, elevated MMPs in the brain may worsen vascular injury by disrupting the blood-brain barrier, attacking myelin fibers and promoting neuroinflammation. Several stress signals and pathways may trigger the secretion of MMPs, one of which is the extracellular matrix metalloproteinase inducer (EMMPRIN or CD147). While MMPs levels such as MMP-2 has been found to be increased in the cerebrospinal fluid of patients with vascular cognitive impairment, circulating levels of the MMPs as well as EMMPRIN in VaD remain unknown. Methods 29 non-cognitive impaired (NCI) controls and 38 VaD subjects were included in the present cross-sectional analyses. Comprehensive clinical, neuropsychological and neuroimaging assessments were performed for all subjects. Blood samples were collected, and serum MMP-2, MMP-9 and EMMPRIN levels were measured using sandwich ELISAs. Results Serum MMP-2 and EMMPRIN levels were significantly higher in VaD as compared to NCI. After adjusting for vascular risk factors, association between higher EMMPRIN levels and VaD remained significant. Furthermore, serum EMMPRIN levels were positively correlated with MMP-2 levels, among all subjects as well as within VaD subjects only. Conclusion Increased EMMPRIN and MMP-2 serum levels suggest ECM and vascular injury, and thus may be a useful clinical biomarker and a potential therapeutic target for VaD. Keywords: vascular dementia (VaD), Matrix metalloprotease (MMP), MMP-2, MMP-9, EMMPRIN (CD147) Conference: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019. Presentation Type: Poster Presentation Topic: Miscellaneous Citation: Chai Y, Chen C, Koo E and Lai M (2019). Increased EMMPRIN Serum Levels in Vascular Dementia Positively Correlate with Matrix Metalloproteinase 2. Front. Pharmacol. Conference Abstract: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”. doi: 10.3389/conf.fphar.2019.63.00012 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Oct 2018; Published Online: 17 Jan 2019. * Correspondence: Ms. Yuek Ling Chai, National University of Singapore, Singapore, Singapore, yuekling@u.nus.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Yuek Ling Chai Christopher P Chen Edward HM Koo Mitchell KP Lai Google Yuek Ling Chai Christopher P Chen Edward HM Koo Mitchell KP Lai Google Scholar Yuek Ling Chai Christopher P Chen Edward HM Koo Mitchell KP Lai PubMed Yuek Ling Chai Christopher P Chen Edward HM Koo Mitchell KP Lai Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.