Abstract
A novel influenza A(H1N1)2009 variant with mildly reduced oseltamivir and zanamivir sensitivity has been detected in more than 10% of community specimens in Singapore and more than 30% of samples from northern Australia during the early months of 2011. The variant, which has also been detected in other regions of the Asia-Pacific, contains a S247N neuraminidase mutation. When combined with the H275Y mutation, as detected in an oseltamivir-treated patient, the dual S247N+H275Y mutant had extremely high oseltamivir resistance.
Highlights
The emergence and global spread in 2007/08 of an oseltamivir-resistant seasonal influenza A(H1N1) variant containing a histidine to tyrosine substitution (H275Y) in the neuraminidase (NA), demonstrated the potential for drug-resistant influenza viruses to arise and spread within the community in the absence of drug-selective pressure [1]
Since the start of the 2009 pandemic, the oseltamivir-resistant H275Y variant has only been detected on rare occasions in pandemic influenza A(H1N1)2009 community specimens (
From April 2009 to December 2010, over 2,900 influenza A(H1N1)2009 influenza viruses from the Asia-Pacific region were analysed for NA inhibitor (NAI) sensitivity with only 23 H275Y oseltamivir-resistant viruses detected (0.8%), and virtually all of the remaining strains being fully sensitive to both oseltamivir and zanamivir
Summary
The emergence and global spread in 2007/08 of an oseltamivir-resistant seasonal influenza A(H1N1) variant containing a histidine to tyrosine substitution (H275Y) in the neuraminidase (NA), demonstrated the potential for drug-resistant influenza viruses to arise and spread within the community in the absence of drug-selective pressure [1]. Since the start of the 2009 pandemic, the oseltamivir-resistant H275Y variant has only been detected on rare occasions in pandemic influenza A(H1N1)2009 community specimens (
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