Abstract
The biochemical status of μ-opioid receptors in suicide was evaluated by [ 3H]DAGO specific binding in postmortem human brains from 15 suicide victims and 15 controls. The density ( B max ) in frontal cortex and thalamus was directly correlated with age. In the frontal cortex and caudate but not in the thalamus of suicide victims the density of μ-opioid receptors was 36–39% higher than in controls. K D values in suicide victims were similar to those in control group (range 1.4–2.2 nM). The results suggest an increase of μ-opioid receptors in suicide associated to some brain areas showing the μ 2-opioid receptor subtype.
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