Abstract
This study investigated the role of cyclic AMP in the inhibition of [ 3H]5-hydroxytryptamine ([ 3H]5-HT) release mediated through the 5-HT 1D autoroceptor using slices of guinea-pig cerebral cortex. Forskolin, dibutyryl-cyclic AMP and rolipram, which increase intracellular cyclic AMP by different mechanisms, all attenuated the inhibitory effect of the autoreceptor agonist 5-carboxamidotryptamine. These results indicate that modulation of cyclic AMP production affects 5-HT 1D autoreceptor function.
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Schedule a callMore From: European Journal of Pharmacology: Molecular Pharmacology
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