Increased Corrected QT Interval (QTc) in First Nations Women of Northern British Columbia with Systemic Lupus Erythematosus (SLE)

Fritha A Munday

doi:10.23937/2378-2951/1410072

Abstract

Increased Corrected QT Interval (QTc) in First Nations Women of Northern British Columbia with Systemic Lupus Erythematosus (SLE)

Highlights

Long QT Syndrome (LQTS), congenital or acquired, is characterized by a prolonged QT interval identified on an electrocardiogram (ECG) predisposing to arrhythmias, ventricular fibrillation, cardiac arrest and sudden death [1]
Individuals diagnosed with LQTS and their relatives participated in our early studies, which led to the identification of a novel c
The mean QTc of each of the four groups showed a descending trend (Figure 1): mutation positive individuals had the highest mean QTc (473.3 ± 26 ms) followed by Systemic Lupus Erythematosus (SLE) patients (466.4 ± 34 ms), relatives of SLE patients (451 ± 20 ms) and mutation negative individuals related to a mutation positive person (434.8 ± 24 ms)

Summary

Introduction

Long QT Syndrome (LQTS), congenital or acquired, is characterized by a prolonged QT interval identified on an electrocardiogram (ECG) predisposing to arrhythmias, ventricular fibrillation, cardiac arrest and sudden death [1]. Congenital LQTS is relatively rare, affecting an estimated 1:2000 [8], but it is disproportionately prevalent (~1:120) in a Canadian First Nations community in northern British Columbia (the Gitxsan). Individuals diagnosed with LQTS and their relatives participated in our early studies, which led to the identification of a novel c.613. A prolonged QTc, cardiac arrest and sudden cardiac death correlates with mutation positive status, supporting that it predisposes individuals to LQTS [10]

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Conclusion