Increased compound heterozygous filaggrin mutations in severe atopic dermatitis in the United States

Abstract

534 Filaggrin mutations are common in a US group of white patients with severe atopic dermatitis (48.5%). Filaggrin mutation analysis in patients with severe atopic dermatitis may be useful for the clinician because it provides a genetic basis to the severity of the disease process and predicts the atopic march as a loss of function mutations confer genetic risks to the development of peanut allergy, allergic rhinitis, and asthma in the presence of eczema. New therapies are being developed to augment filaggrin expression in atopic dermatitis skin and patients will filaggrin mutations may benefit the most from this information. 3702delG/WT 0.0 (0.0)