Increased collagenase activity in early aneurysmal dilatation.

Abstract

Increased collagenase activity has been implicated as a basic abnormality in aortic aneurysm formation. We studied a localized aneurysmal change, poststenotic dilatation, and its relation to collagenase and elastase activity of the aortic wall. Cynomolgus monkeys underwent midthoracic aortic coarctation to produce poststenotic dilatation. Serial angiography showed that poststenotic dilatation was minimal or absent at 10 days, just discernible at 3 months, and prominent at 6 months. At the 3-month time interval, collagenase activity in the region of the poststenotic dilatation increased twofold compared with the same region in aortas from animals without poststenotic dilatation (p less than 0.05). There was no change in aortic elastase activity. These data indicate that collagenolysis and aneurysmal dilatation may be induced by local modifications of pressure and/or flow. Increased collagenase activity associated with abdominal aortic aneurysms may not represent an intrinsic metabolic defect but rather a response to altered hemodynamic conditions.