Abstract
Objective: To examine the phenotypes of endothelial microparticles and platelet microparticles in order to identify a sensitive endothelial microparticle biomarker for monitoring endothelial dysfunction in patients with coronary artery disease, and to examine the mechanisms underlying endothelial dysfunction. Methods: Thirty-three coronary artery disease patients and 53 healthy subjects were recruited. The absolute numbers of endothelial microparticles and platelet microparticles were measured by flow cytometry, and the clinical characteristics of patients and healthy subjects were recorded. Spearman’s correlation analysis and multiple linear regression analysis were performed to analyse the correlation between endothelial microparticles and platelet microparticles, and between microparticles and clinical data. Results: There was a significant difference in the number of CD31+/CD42b- endothelial microparticles and CD62E+ endotheial microparticles between patients with coronary artery diease and healthy subjects (p<0.05). Conclusion: Both endothelial apoptosis and activation play an important role in coronary artery disease, although endothelial apoptosis plays the major role. Endothelial microparticles may be used to monitor endothelial dyfunction in patients with coronary artery disease.
Highlights
Endothelial Dysfunction (ED) is an important pathophysiological mechanism that underlies the development of Coronary Artery Disease (CAD) [1]
Some studies report that CD31+Endothelial Microparticles (EMP) are shed from apoptotic endothelial cells, whereas CD62E+ EMP are shed by activated endothelial cells [3]
The results showed that neither CD62E+ EMP nor CD31+ EMP correlated with clinical parameters
Summary
Endothelial Dysfunction (ED) is an important pathophysiological mechanism that underlies the development of Coronary Artery Disease (CAD) [1]. It is important to identify new biomarkers that can be used to monitor ED in CAD and to identify the underlying mechanisms. ED is determined by the balance between endothelial activation and endothelial apoptosis. Endothelial Microparticles (EMP) are derived from endothelial cells in response to endothelial activation and apoptosis. Some studies report that CD31+EMP are shed from apoptotic endothelial cells, whereas CD62E+ EMP are shed by activated endothelial cells [3]. The aims of the present study were to examine the phenotypes of EMP and Platelet Microparticles (PMP) in order to identify a sensitive endothelial microparticle biomarker for monitoring ED in CAD, and to examine the mechanisms underlying ED
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