Increased Capsaicin Sensitivity in Patients With Severe Asthma Is Associated With Worse Clinical Outcome

Abstract

Y Kanemitsu, K Fukumitsu, R Kurokawa. Am J Respir Crit Care Med . 2020;201(9):1068–1077 To study the role of capsaicin cough reflex sensitivity (C-CS) as a marker of airway neuronal dysfunction in severe asthmatics. The study included 157 adults with asthma based on symptoms, positive methacholine challenge, and treatment response to inhaled corticosteroids, of which 122 patients had severe asthma based on Global Initiative for Asthma (GINA) guidelines. Patients were enrolled between November 2016 and October 2019. Current smokers were excluded. This is an observational prospective cohort study. All enrolled participants completed the asthma control test (ACT), …