Increased Burden of Pertussis Among Adolescents and Adults With Asthma or COPD in the United States, 2007 to 2019

Abstract

Individuals with chronic respiratory illnesses may be at higher risk of pertussis infection and severe pertussis than those without. What is the incidence of pertussis and pertussis complications in cohorts with preexisting asthma or COPD vsage- and sex-matched control patients from the general population in the United States? This observational, retrospective study included individualsaged ≥ 10 years from an administrative health claims system between 2007 and 2019. Individuals with preexisting asthma or COPD were matched with control patients from the general population. The incidence of pertussis infections and pertussis-related complications were assessed overall and by age. The incidence of asthma or COPD exacerbations was also assessed before and after diagnosis of pertussis. In the general population, incidence per 100,000 person-years of pertussis infection ranged from 5.33 in 2007 to 13.04 in 2012, with highest (all years) in those aged 10 to 17 years. The risk of pertussis was higher for the asthma (rate ratio, 3.57; 95%CI, 3.25-3.92) and COPD cohorts (rate ratio, 1.83; 95%CI, 1.57-2.12) than the general population. Those with asthma or COPD had a 4.12-fold (95%CI, 3.16-5.38) and 2.82-fold (95%CI, 2.14-3.27) increased risk of pertussis with complications than the general population, respectively. Exacerbations were most frequent 30days before pertussis diagnosis (incidence rate [IR], 25%) in the asthma cohort and 30days before (IR, 26%) and after (IR, 22%) pertussis diagnosis, remaining elevated for 180days after diagnosis, in the COPD cohort. Among these insured individuals, asthma or COPD increased the risk for pertussis disease and complications vsthe general population. COPD and asthma exacerbations were observed most frequently within 30days of receiving a pertussis diagnosis and remained elevated, suggesting a long-term effect of pertussis in the COPD cohort.