Increased body mass index adversely affects dyslipidemias, blood pressure and inflammation in men and women with metabolic syndrome (LB365)

Abstract

We investigated the effects of body mass index (BMI) on the parameters of metabolic syndrome (MetS) in men (n = 97) and women (n = 165) with MetS. MetS parameters were determined using the National Cholesterol Education Program: Adult Treatment Panel III (NCEP: ATP III) criteria. We classified subjects into four BMI subgroups: normal MetS (BMI < 24.9 kg/m2, n= 11); overweight MetS (BMI 26‐29.9 kg/m2 n =57); obese MetS (30‐39.9 kg/m2, n =157) and morbidly obese MetS (BMI > 40 kg/m2, n = 35). In addition to the expected significant differences between groups in body weight and waist circumference (P < 0.001), there were significant differences in plasma lipids, blood pressure, plasma insulin and C‐reactive protein (CRP) associated with BMI classification.HDL‐cholesterol was significantly lower in the morbidly obese MetS group (43 ± 9 mg/dL) when compared to MetS subjects with a normal BMI (51 ± 11 mg/dL). In contrast, LDL‐cholesterol was incrementally higher as BMI increased (normal MetS: 111.7 ± 16.9 mg/dL vs. morbidly obese MetS: 129.0 ± 12.5 mg/dL).Similarly both diastolic and systolic blood pressures were lowest in the normal BMI group and higher in the other BMI groups. Plasma insulin and CRP were also significantly increased from the lowest to the highest BMI (P < 0.05). These findings suggest that even in those with MetS, as BMI increases, there is a higher risk of dyslipidemias, hypertension and inflammationGrant Funding Source: Egg Nutrition Center and Dairy Council