Abstract
Abstract Biliary cadmium (Cd) excretion associated with reduced glutathione (GSH) following treatments of cadmium chloride (CdCl2) to female rats fed a 20% ethanol solution for six days was investigated and compared with Cd excretion in male rats. Cadmium chloride injection alone in female rats caused a 3.9‐fold increase in cumulative GSH in bile up to 12 h after treatment compared to control female rats. Cadmium chloride injection of ethanol‐fed rats caused a 5.0‐fold increase in biliary GSH compared to controls. A similar pattern was observed in the biliary concentration of Cd. At 12 h after CdCl2 treatment, the cumulative content of Cd in bile for the CdCl2 and ethanol group was 7.9% of the administered dose. This was almost twice that seen in the CdCl2 alone group (4.2%). The majority of biliary excretion of both GSH and Cd were excreted into bile within 6 h after CdCl2 injection. The enhancement of Cd excretion into bile presented by combination treatment with CdCl2 and ethanol in female rats was hig...
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