Abstract
Increased asymmetric dimethylarginine and nitric oxide levels in patients with migraine
Highlights
Migraine is a common, chronic and disabling neurovascular disorder that characterized by severe headache attacks with photophobia, nausea, vomiting, autonomic symptoms, and in some patients with aura involving neurological symptoms
Nitric oxide, which is formed by the constitutive isoforms of NO synthase, endothelial nitric oxide synthase and neuronal nitric oxide synthase, plays an important roles in the regulation of cerebral blood flow and cell viability and in the protection of nerve cells or fibers against pathogenic factors associated with neurological disorders [3]
Our study showed that plasma concentrations of Asymmetric dimethylarginine (ADMA) and NO were elevated in migraine patients as compared to control subjects
Summary
Chronic and disabling neurovascular disorder that characterized by severe headache attacks with photophobia, nausea, vomiting, autonomic symptoms, and in some patients with aura involving neurological symptoms. It has been reported that nitric oxide (NO) plays a role during trigeminovascular inflammation occurring during migraine attacks [2]. Nitric oxide, which is formed by the constitutive isoforms of NO synthase, endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS), plays an important roles in the regulation of cerebral blood flow and cell viability and in the protection of nerve cells or fibers against pathogenic factors associated with neurological disorders [3]. Oxidative stress due to increased NO has been found especially during attacks in patients with migraine [4, 5]. It is emphasized that neurogenic inflammation, endothelial dysfunction and oxidative stress have a role in migraine pathogenesis [1,2,3,4,5]
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