Abstract

Two-dimensional (2D) speckle tracking imaging (STI) is a non-invasive method used to assess subtle changes in left ventricular (LV) function such as strain and rotational dynamics. However, 2D methodology is complicated by issues such as the out-of-plane problem inherent in short-axis imaging. In addition, circumferential rotation contributes to three-dimensional (3D) wall deformations and affects tracking accuracy. By using 3D-STI technique, we evaluated LV global longitudinal strain (GLS) and apical rotation in severe aortic stenosis (AS) patients with preserved LV ejection fraction (EF). LV GLS and apical rotation were evaluated using 3D-STI in 20 severe AS patients (79±8years old; aortic valve area 0.7±0.2cm2) with preserved LVEF (68±7%). Data were compared with those of 11 hypertensive LV hypertrophy (LVH) patients (75±10years old, EF=66±4%) and 12 controls (healthy individuals: 30±14years old, EF=63±6%). Compared with LVH patients, severe AS patients had significantly decreased values of GLS (-13.0±2.4 vs. -10.4±2.0%, p=0.008). In contrast, LV rotation was significantly higher in AS than LVH patients (13.9 ±3.0° vs. 10.8 ±2.5°, p=0.007). There was no significant difference in stroke volume index among three groups. In these three groups, severe AS patients had significantly decreased values of GLS [analysis of variance (ANOVA), p<0.001] and increased LV rotation (ANOVA, p<0.001). In severe AS patients, impaired GLS existed although LVEF was preserved. However, LV rotation was increased in patients with severe AS probably to maintain the LV stroke volume.

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