Abstract
Background Cardiovascular disease (CVD) is the number one cause of mortality in patients with type 1 diabetes (T1D). There is evidence that maladaptive vascular changes associated with diabetes have already occurred as early as adolescence and that markers of aortic stiffness has been shown to be important predictors of early CVD risk. In this study, we evaluate the central distensibility, a measure of aortic stiffness by MRI, in adolescents with T1D compared to non-diabetic controls.
Highlights
Cardiovascular disease (CVD) is the number one cause of mortality in patients with type 1 diabetes (T1D)
There is evidence that maladaptive vascular changes associated with diabetes have already occurred as early as adolescence and that markers of aortic stiffness has been shown to be important predictors of early CVD risk
We evaluate the central distensibility, a measure of aortic stiffness by MRI, in adolescents with T1D compared to non-diabetic controls
Summary
Cardiovascular disease (CVD) is the number one cause of mortality in patients with type 1 diabetes (T1D). There is evidence that maladaptive vascular changes associated with diabetes have already occurred as early as adolescence and that markers of aortic stiffness has been shown to be important predictors of early CVD risk. We evaluate the central distensibility, a measure of aortic stiffness by MRI, in adolescents with T1D compared to non-diabetic controls
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