Abstract
SummaryBackgroundOxidative stress may be involved in the pathogenesis of every human disease. To understand its possible role in benign prostatic hyperplasia (BPH), we measured the overall oxidative status of patients with BPH and the serum activity of the high density lipoprotein (HDL)-related antioxidant enzymes paraoxonase 1 (PON1) and arylesterase (ARE).MethodsFifty-six urology outpatient clinic patients with BPH (mean age 64±8.6 years) were prospectively included in the study. Forty volunteer healthy controls from the laboratory staff (mean age 62±10 years) were enrolled for comparison. Serum total antioxidant status (TAS), total oxidant status (TOS), PON1, ARE, and HDL levels were measured by commercially available, ready-to-use kits.ResultsSerum TAS and HDL levels were significantly lower in the BPH group than in the control group (P=0.004 and P=0.02, respectively). No significant between-group differences were observed for TOS levels or PON1 and ARE enzyme activities (P=0.30, P=0.89, and P=0.74, respectively). In the BPH group, the calculated parameters PON1/HDL and ARE/HDL were significantly higher (P=0.02 and P=0.04, respectively).ConclusionsOur findings agree with the previous reports of impaired oxidant/antioxidant balance in BPH patients. The activities of HDL-related enzymes between groups with significantly different HDL levels may be deceptive; adjusted values may help to reach more accurate conclusions.
Highlights
Benign prostatic hyperplasia (BPH) is a nonmalignant overgrowth of prostatic glandular and stromal tissue
Fifty-six patients with benign prostatic hyperplasia who had presented to the Urology Outpatient Clinic were prospectively included in the study
Final diagnosis of each BPH patient was confirmed by histopathologic evaluation of prostate needle biopsies
Summary
Benign prostatic hyperplasia (BPH) is a nonmalignant overgrowth of prostatic glandular and stromal tissue. The area where the prostate surrounds the urethra is the main cause of clinical manifestations. BPH is a major concern in the 21st century, a time with the largest senior population in human history. The prostate normally enlarges to some degree in all men with advancing age. Some men with histologically proven BPH have no clinical complications, whereas others experience changes in voiding patterns that lead them to seek medical care and may require surgical treatment. BPH is apparently a chronic indolent disease that manifests over a span of decades [1]. Reviews of medical records show evidence of a dramatic rise in the prevalence of histologically proven BPH from approximately 8% of men in their third decade to approximately 90% by their ninth decade
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