Abstract
It has been shown that blood pressure (BP) values measured in obese subjects are higher than the individuals with normal weight, even in normotensive limits. However, data concerning the Ambulatory Arterial Stiffness Index (AASI) and blood pressure load in normotensive obese subjects is lacking. This study was aimed to compare the ambulatory arterial stiffness index and blood pressure load in normotensive obese and healthy controls. One hundred normotensive obese and one hundred normal weight subjects were included in this study. All subjects underwent 24-hour ambulatory blood pressure monitoring. Ambulatory arterial stiffness index was calculated from 24-hour ambulatory blood pressure monitoring records. Ambulatory arterial stiffness index was defined as one minus the regression slope of unedited 24-h diastolic on systolic blood pressures. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) load values were calculated from 24-hour ambulatory blood pressure monitoring analysis. Ambulatory arterial stiffness index of the obese subjects was significantly higher than the healthy controls (0.48±0.2 vs. 0.33±0.11, p<0.001). 24-hours systolic blood pressure and diastolic blood pressure loads were significantly higher in obese subjects. Logistic regression analysis revealed that body mass index (BMI) was an independent predictor for an abnormal ambulatory arterial stiffness ındex (≥0.50) (OR: 1.137, 95% CI: 0.915-1.001, p=0.004). Blood pressure load and ambulatory arterial stiffness index are increased in normotensive obese patients. Moreover, body mass index is an independent predictor for an abnormal ambulatory arterial stiffness index. Our results indicate that obese subjects are at higher risk for future cardiovascular events despite normal office BP levels.
Highlights
Obesity, which may give rise to the development of various diseases, is currently one of the most important health problems globally
Systolic blood pressure (SBP) and diastolic blood pressure (DBP) have been found increased, both in daytime and night time, in obese subjects compared to healthy controls. 24-hours SBP and DBP loads were significantly higher in obese subjects compared to healthy controls
In our study we showed for the first time that blood pressure (BP) load and Arterial Stiffness Index (AASI) are increased in normotensive obese patients compared to healthy controls
Summary
Obesity, which may give rise to the development of various diseases, is currently one of the most important health problems globally. The prevention and early diagnosis of the elevated blood pressure (BP) may help reducing the complications associated with hypertension. The relationship between obesity and hypertension has been well established. The blood pressure values measured in obese patients are higher than normal weight subjects even in the normotensive range[1]. Office BP measurements may be insufficient in detection of the elevated BP.
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