Increase of urinary malondialdehyde level by bisphenol A exposure: a longitudinal panel study

Jin Hee Kim,Yun-Chul Hong

doi:10.1186/s12940-017-0221-9

Abstract

BackgroundTo verify oxidative stress as a possible mechanism that establishes a relationship between exposure to bisphenol A (BPA) and adverse health outcomes in the elderly Korean population, we evaluated the relation between visit-to-visit variations in urinary BPA and oxidative stress biomarker.MethodsTo assess the relation between BPA and urinary malondialdehyde (MDA) as an oxidative stress biomarker, we used a mixed effect model after controlling for age, sex, BMI, drinking status, exercise, urinary cotinine level, PM10 on lag day 2, and mean temperature and dew point on the day. The relation between exposure to BPA and MDA level by sex of participants and polymorphisms of oxidative stress-related genes (COX2, EPHX1, HSP70-hom, PON1, eNOS, CAT, DRD2, SOD2, and MPO) was also evaluated.ResultsA significant association was found for BPA with MDA in both male and female elderly participants (male, β = 0.19 and p = 0.0003; female, β = 0.18 and p < .0001; and total, β = 0.18 and p < .0001). Furthermore, the association of BPA with MDA was found regardless of any genotype of the nine oxidative stress-related genes.ConclusionsThe results of our study suggest a strong association of BPA with oxidative stress, not related with sex and oxidative stress-related gene polymorphisms.

Highlights

To verify oxidative stress as a possible mechanism that establishes a relationship between exposure to bisphenol A (BPA) and adverse health outcomes in the elderly Korean population, we evaluated the relation between visit-to-visit variations in urinary BPA and oxidative stress biomarker
Particulate matter less than 10 μm (PM10) concentration and meteorological factors In a previous study for the delayed effects of PM10 on MDA level, significant associations of PM10 on lag day 2 and outdoor temperature and dew point on the day with MDA level were found [18] and we adjusted for these factors in our models
This study showed a strong association of BPA with MDA, not related with sex or with the genetic polymorphisms of nine oxidative stress-related genes (COX2, Epoxidehydrolase 1 (EPHX1), HSP70-hom, paraoxonase 1 (PON1), endothelial nitric oxide synthase (eNOS), CAT, dopamine receptor D2 (DRD2), superoxide dismutase 2 (SOD2), and MPO)

Summary

Introduction

To verify oxidative stress as a possible mechanism that establishes a relationship between exposure to bisphenol A (BPA) and adverse health outcomes in the elderly Korean population, we evaluated the relation between visit-to-visit variations in urinary BPA and oxidative stress biomarker. Several studies have suggested that oxidative stress is a possible mechanism that establishes the relation between exposure to BPA and adverse health outcomes [8, 9]. We estimated the effect of BPA on MDA level by sex of participants and polymorphisms of oxidative stress-related genes (COX2, EPHX1, HSP70-hom, PON1, eNOS, CAT, DRD2, SOD2, and MPO)

Methods

Results

Discussion

Conclusion