Abstract
Oral administration of probenecid augmented urinary clearance of, trichloroacetic acid precipitable 131I-insulin in six men who were injected with tracer dose of 131I-insulin intravenously. The increments were 16 to 423 % above the control value (P<0.05). In other eight men, endogenous insulin in urine and plasma was measured by radioimmunoassay method. Apparently increased responses in urinary insulin excretion and urinary insulin clearance were observed after probenecid administration. The percentage increases of the insulin excretion and the insulin clearance beyond the control values were 2 to 200 (P<0.01) and 7 to 200 (P<0.01), respectively.It was suggested that insulin was reabsorbed at the proximal convoluted tubules and that probenecid affected this reabsorption mechanism.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
