Abstract
Introduction: Most patients with small-cell lung cancer (SCLC) suffer from extensive disease and early metastatic spread, with an unimproved poor prognosis. The mechanisms of metastatic spread are still poorly understood. Earlier animal models of SCLC were of limited clinical value, as the process of metastasis was inefficient and had to be initialized by i.v. injection of human SCLC cells (dissemination) or orthotopic transplantation. The aim of this study was to develop a xenograft mouse model of spontaneous SCLC metastasis, and to test different SCLC cell lines in this system. Primary SCLC growth and metastatic pattern was compared within scid mice (lacking T- and B- cells) and the T-, B- and NK cell lacking double knock out perforin/recombination activating complex 2 (pfp/rag2) mice.
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