Abstract
In a previous study we evaluated muscle blood flow and muscle metabolism in patients diagnosed with chronic fatigue syndrome (CFS). To better understand muscle metabolism in CFS, we re-evaluated our data to calculate free Magnesium levels in skeletal muscle. Magnesium is an essential cofactor in a number of cell processes. A total of 20 CFS patients and 11 controls were evaluated. Phosphorus magnetic resonance spectroscopy from the medial gastrocnemius muscle was used to calculate free Mg2+ from the concentrations and chemical shifts of Pi, PCr, and beta ATP peaks. CFS patients had higher magnesium levels in their muscles relative to controls (0.47 + 0.07 vs 0.36 + 0.06 mM, P < 0.01), although there was no difference in the rate of phosphocreatine recovery in these subjects, as reported earlier. This finding was not associated with abnormal oxidative metabolism as measured by the rate of recovery of phosphocreatine after exercise. In summary, calculation of free Mg2+ levels from previous data showed CFS patients had higher resting free Mg2+ levels compared to sedentary controls.
Highlights
In a previous study we evaluated muscle blood flow and muscle metabolism in patients diagnosed with chronic fatigue syndrome (CFS) [1]
CmsFuioegbamjuesrpucetarsre1idsobny oPfCfrereecmoavgenreysinumthaenldegosxoidf aCtiFvSe amnedtacboonltirsoml Comparison of free magnesium and oxidative metabolism measured by PCr recovery in the legs of CFS and control subjects
Our analysis showed CFS patients to have higher magnesium levels in their muscles relative to controls, which is a unique observation
Summary
In a previous study we evaluated muscle blood flow and muscle metabolism in patients diagnosed with chronic fatigue syndrome (CFS) [1]. In this study as well as others [2,3,4], it has not been clear whether muscle metabolism is abnormal in CFS. To better understand muscle metabolism in CFS, we re-evaluated our data to calculate free Magnesium levels in skeletal muscle. Any alteration in free Mg2+ could have significant consequences in muscle metabolism.
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