Abstract
BackgroundIt is known that the increased level of IDL and oxidized LDL are associated with risk of cardiovascular disease, and the lipoprotein abnormalities accelerate atherosclerosis. Cardiovascular disease is a major cause of mortality in chronic kidney disease patients with hemodialysis treatment (HD-Ps). Therefore, the estimation of lipoprotein profiles is important for prevention of cardiovascular disease in HD-Ps. We previously established an anion-exchange chromatographic method for measurement of cholesterol level in subclasses of HDL and LDL, IDL, VLDL, and chylomicron. An electronegative-LDL-fraction contained minimally oxidized-LDL. Lipoprotein profile can be accurately and conveniently determined by the new method.FindingIn this study, lipoprotein profiles in HD-Ps and age-matched healthy subjects were estimated by using our established anion-exchange chromatographic method. The ratio of electronegative-LDL-cholesterol to total LDL-cholesterol and IDL-cholesterol in HD-Ps were significant higher than those in healthy subjects.ConclusionsThe results suggest that the ratio of electronegative-LDL-cholesterol to total LDL-cholesterol and IDL-cholesterol obtained by the new method may serve as useful markers for risk of cardiovascular disease in HD-Ps.
Highlights
Cardiovascular disease is a major cause of mortality in chronic kidney disease patients with hemodialysis (HDPs) [1]
The results suggest that the ratio of electronegative-LDL-cholesterol to total LDL-cholesterol and IDL-cholesterol obtained by the new method may serve as useful markers for risk of cardiovascular disease in chronic kidney disease patients with hemodialysis treatment (HD-Ps)
Shoji et al reported that the cholesterol levels of HDL and LDL were lower, and IDL and VLDL were higher in end-stage renal disease [2]
Summary
Cardiovascular disease is a major cause of mortality in chronic kidney disease patients with hemodialysis (HDPs) [1]. It is known that HDL and LDL are decreased, and IDL and VLDL were increased in end-stage renal disease [2]. We previously reported an anion-exchange chromatographic method (AEX-HPLC) for measurement of cholesterol level in two HDL-subclasses, two LDL-subclasses, IDL, VLDL, and chylomicron, and the cholesterol levels of electronegative-LDL-fraction, which is eluted later from the column, in patients with coronary artery disease were. Cardiovascular disease is a major cause of mortality in chronic kidney disease patients with hemodialysis treatment (HD-Ps). The estimation of lipoprotein profiles is important for prevention of cardiovascular disease in HD-Ps. We previously established an anion-exchange chromatographic method for measurement of cholesterol level in subclasses of HDL and LDL, IDL, VLDL, and chylomicron. Lipoprotein profile can be accurately and conveniently determined by the new method
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