Abstract
BackgroundIn this study, we aimed to compare the choroidal thickness between a group of Korean patients with inactive thyroid eye disease (TED) and a control group of Korean patients and to analyze the variables affecting choroidal thickness.MethodsPatients diagnosed with inactive TED and without TED who underwent optical coherence tomography and axial length measurements were included and classified into the TED group and control group. Choroidal thickness was measured using images acquired in enhanced depth imaging (EDI) mode by cirrus HD-OCT (Carl Zeiss Meditec Inc., Dublin, CA, UAS) at the central fovea and points 1.5 mm nasal and 1.5 mm temporal from the central fovea using a caliper tool provided by OCT software.ResultsThe mean central foveal choroidal thickness was 294.2 ± 71.4 µm and 261.1 ± 47.4 µm in the TED and control groups, respectively, while the mean temporal choroidal thickness was 267.6 ± 67.5 µm and 235.7 ± 41.3 µm in the TED and control groups, respectively, showing significant differences between the two groups (P = 0.011, P = 0.008). The mean nasal choroidal thickness was 232.1 ± 71.7 µm and 221.1 ± 59.9 µm in the TED and control groups, respectively, showing no significant difference between the two groups (P = 0.421). Multivariate regression analysis showed the factors affecting central foveal choroidal thickness were age, axial length, and degree of exophthalmos, and factors affecting temporal choroidal thickness were age and degree of exophthalmos.ConclusionsCentral foveal and temporal choroidal thickness were significantly thicker in patients with inactive TED than in control subjects, while age, axial length, and degree of exophthalmos were identified as major factors affecting choroidal thickness.
Highlights
In this study, we aimed to compare the choroidal thickness between a group of Korean patients with inactive thyroid eye disease (TED) and a control group of Korean patients and to analyze the variables affecting choroidal thickness
Choroidal thickness was measured using images acquired in enhanced depth imaging (EDI) mode by cirrus High-definition optical coherence tomography (HD-OCT) (Carl Zeiss Meditec Inc., Dublin, CA, UAS)
Measurement of choroidal thickness has recently been made possible through imaging by OCT in EDI mode and various studies have reported on changes in choroidal thickness in various diseases
Summary
We aimed to compare the choroidal thickness between a group of Korean patients with inactive thyroid eye disease (TED) and a control group of Korean patients and to analyze the variables affecting choroidal thickness. Thyroid eye disease (TED) is an autoimmune disorder characterized by proliferation of the orbital fat tissue and inflammation of the orbital connective tissue and extraocular muscles. TED is observed in approximately 25–50% of patients with Graves’ disease and 2% of patients with thyroiditis [1]. TED present with mild symptoms, the condition may progress into a more severe form in approximately 3–5% of the patients. TED involves proliferation of orbital fibro-adipose tissues and infiltration of inflammatory cells, causing an increase in orbital tissue volume. Clinical signs of TED include dry eyes, exposure keratopathy, exophthalmos, diplopia, and decreased visual acuity [2].
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