Abstract
Adrenal weight and the concentration of corticosterone and glucose in plasma of male Wistar rats, dosed orally with fenitrothion (7.25 or 14.5 mg/kg/day) for 28 days were investigated. A significant increase in the relative weight of adrenals was observed 2 weeks after treatment commenced, but was preceded by an increase in plasma corticosterone and glucose levels, which reached a maximum within 7 days. These results indicate that the repeated administration of fenitrothion might produce changes in adrenal function in rats.
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