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Abstract
β-Endorphin and methionine(met)-enkephalin in cerebrospinal fluid (CSF) were measured before and after removal of an adrenocorticotropic hormone-(ACTH)-secreting adenoma in Cushing's disease by a sensitive radioimmunoassay and a radio-receptor assay, respectively. After tumor resection, the level of ACTH in plasma markedly decreased from 82.6 ± 22.7 pg/ml to 16.7 ± 4.1 pg/ml (mean ± S.E., n = 4). It was found that the level of β-endorphin in CSF significantly increased from 32.0 ± 4.5 pg/ml to 61.8 ± 10.7 pg/ml ( P < 0.05) after tumor resection, while the level of metenkephalin in CSF remained unaltered. This result suggests that hypophysectomy induces an increase of β-endorphin in CSF.
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