Increase in Renin Release after Sinoaortic Denervation and Cervical Vagotomy in Anesthetized Dogs (II)

Abstract

ConclusionsStudies were done to clarify the mechanism whereby sinoaortic denervation and cervical vagotomy increase plasma renin activity (PRA). Dogs were subjected to renal denervation and some of them to adrenalectomy as well. Seven to ten days later, sinoaortic denervation and vagotomy were done under pentobarbital anesthesia. In intact animals, mean PRA increased after sinoaortic denervation and increased further after cervical vagotomy. In dogs with the kidneys denervated, PRA increased after sinoaortic denervation. Cervical vagotomy in these animals caused a further slight, but not statistically significant, increase in mean PRA. In adrenalectomized dogs with the kidneys denervated, PRA did not change after sinoaortic denervation and cervical vagotomy. These results suggest that the increase in PRA after sinoaortic denervation probably results both from increased sympathetic discharge to the kidneys and from catecholamines released from the adrenal medulla, whereas the increase in PRA after cervical...