Abstract
We describe the frequency, demographic and clinical features, and visual outcomes of ocular syphilis infections observed during 2012–2015 at a tertiary reference center in Paris, France. Twenty-one cases (29 eyes) were identified. The occurrence of ocular syphilis increased from 1 case in 2012 to 5 cases in 2013, 6 cases in 2014, and 9 cases in 2015 (2.22–25.21/1,000 individual patients/year for the period). Among case-patients, an annual 20%–33% were co-infected with HIV. Seventy-six percent of ocular syphilis infections occurred in men who have sex with men. Seventy-five percent of case-patients had a good final visual outcome (best-corrected visual acuity >0.3 logMAR score). Visual outcome was worse for HIV-positive patients than for HIV-negative patients (p = 0.0139). At follow-up, the best visual outcomes were observed in patients whose mean time from first ocular symptom to consultation was 15 days (SD +19 days).
Highlights
We describe the frequency, demographic and clinical features, and visual outcomes of ocular syphilis infections observed during 2012–2015 at a tertiary reference center in Paris, France
Visits to outpatient clinics for confirmed ocular syphilis increased from 1 in 2012 to 5 in 2013, 6 in 2014, and 9 in 2015 (2.22–25.21 visits/1,000 individual patients per year for the period) (Figure 1)
Our study examined the trends in ocular syphilis in patients attending the uveitis clinic in a tertiary uveitis center in France
Summary
Demographic and clinical features, and visual outcomes of ocular syphilis infections observed during 2012–2015 at a tertiary reference center in Paris, France. Seventy-five percent of case-patients had a good final visual outcome (best-corrected visual acuity >0.3 logMAR score). At follow-up, the best visual outcomes were observed in patients whose mean time from first ocular symptom to consultation was 15 days (SD +19 days). In 2015, nearly two thirds (62%) of the syphilis cases with information on transmission category were reported in MSM [16]. In this context, we set up a retrospective study to review ocular syphilis cases observed during 2012–2015 in a tertiary reference center in Paris, France. Our objectives were to analyze trends in ocular syphilis frequency, demographic characteristics, clinical severity, and patient outcome
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