Abstract
The level of acetyl-CoA in the livers of alloxan diabetic rats rendered ketotic by withdrawal of insulin and administration of adrenal corticoid hormones and of rats made ketotic by fat feeding is 2.5 – 3 times higher than in untreated controls. This finding is taken as evidence in support of the theory that ketosis occurs as a result of over-production of acetyl-CoA in the liver.
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