Abstract
Although circulating Th-17 (cTh-17) cells are related to inflammatory diseases, its role in HIV immunopathogenesis is not well known. We investigated the association of cTh-17 cells with immune activation (IA), immune exhaustion (IE) and regulatory T-cells (T-regs) in HAART treated virologically controlled (<40 HIV RNA copies/ml) HIV-1 infected patients with poor CD4 T-cell recovery (discordant).
Highlights
Circulating Th-17 cells are related to inflammatory diseases, its role in HIV immunopathogenesis is not well known
We investigated the association of circulating Th-17 (cTh-17) cells with immune activation (IA), immune exhaustion (IE) and regulatory T-cells (T-regs) in HAART treated virologically controlled (
Frequencies of cTh-17 cells were significantly higher in discordant patients than concordant patients (P < 0.0001) and healthy controls (HCs) (P = 0.014). cTh-17 cells frequency correlated inversely with CD4 T-cell percentages and absolute count and directly with CD4-IA and T-reg frequencies
Summary
Circulating Th-17 (cTh-17) cells are related to inflammatory diseases, its role in HIV immunopathogenesis is not well known. We investigated the association of cTh-17 cells with immune activation (IA), immune exhaustion (IE) and regulatory T-cells (T-regs) in HAART treated virologically controlled (
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