Increase in Cerebral Blood Flow After Catheter Ablation of Atrial Fibrillation.

Abstract

Recent studies have found that atrial fibrillation (AF) is a risk factor for cognitive impairment. Brain hypoperfusion is hypothesized as an underlying mechanism of cognitive decline in AF patients. This study sought to assess changes in cerebral blood flow (CBF) and brain volume after catheter ablation of AF. Patients undergoing catheter ablation of AF were enrolled in this prospective study. AF patients being treated with pharmaceuticals alone served as a control group. Brain magnetic resonance imaging was performed before and 6months after catheter ablation. CBF was assessed by 2-dimensional phase-contrast magnetic resonance angiography. Brain volume and bilateral hippocampal volume were measured using FreeSurfer software. Of the 57 study patients (age 64 ± 11 years; 45 men; paroxysmal AF: n=22; nonparoxysmal AF: n=35), 48patients were freed from tachyarrhythmia recurrence beyond a 3-month blanking period. Changes in CBF and brain perfusion over 6months were significantly greater in the study patients than control (CBF: 39.26 vs -34.86mL; P = 0.01, ANCOVA; brain perfusion: 3.78 vs -3.02mL/100mL/min; P = 0.009, ANCOVA), while changes in total brain volume and bilateral hippocampal volume were similar between 2 groups (total brain volume: 2.57 vs -2.15mL; P = 0.32, ANCOVA; bilateral hippocampal volume: 0.03 vs 0.04mL; P = 0.8, ANCOVA). Nonparoxysmal AF at baseline was an independent predictor of an increase in CBF of >32.6mL/min. Catheter ablation of AF has favorable effects on CBF, particularly in nonparoxysmal AF. Our results maypartially explain the association between cognitive decline and AF.