Abstract
Tubocurarine reduced the neurally evoked [ 3H]acetylcholine release in the absence of nicotine, indicating positive nicotinic feedback. Tubocurarine, hhowever, enhanced [ 3H]acetylcholine release after pretreatment with nicotine, a condition which causes desensitization of nicotine autoreceptors. After a nicotine-free period (15–60 min) during which the facilitatory autoreceptors could recover from desensitization, tubocurarine again reduced [ 3H]acetylcholine release. Protection of facilitatory nicotine autoreceptors from desensitization could explain the tubocurarine-induced increase in transmitter release.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
