Abstract
The biosynthesis of the depsipeptide antibiotic beauvericin was studied by feeding submerged cultures of Paecilomyces fumoso-roseus with [ 14C]-labelled precursors. l-Phenylalanine, hydroxyisovaleric acid, l-valine and methyl-labelled methionine were efficiently incorporated into beauvericin, whereas no radioactive depsipeptide was formed with l-leucine and l-tyrosine. [ 14C]Phenylalanine was found to label exclusively the N-methylphenylalanine residues of beauvericin, the N-methylgroups, thereof, were derived from methionine. Beauvericin synthesized in the presence of dl-[2- 14C]hydroxyisovaleric acid or l-[ 14C]valine was specifically labelled in its hydroxy valeryl moieties.
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