Incorporation of Ovalbumin into Carbonate Apatite as a Candidate for Protein Delivery

Abstract

Appropriate biomaterial and controlled size particle are the important component to achieve effective delivery system. Reducing size of the particle is recommended because it can overcome the barriers during cellular uptake. Biomimetic carbonate apatite (CHA) is now considered as candidate for protein delivery because it has high affinity to protein, high biocompatibility and biodegradibility, and increases protein stability. In this study, nano-CHA was prepared and ovalbumin (OVA) protein was incorporated into the CHA particles.