Abstract
The aim of this study was to incorporate tucuma oil (Astrocaryum vulgare) into PolyCaprolactone (PCL) electrospun fibers and evaluate its physicochemical properties and cell viability. FTIR and DRX confirmed that tucuma oil (TO) does not affect the chemical properties of PCL and that the oil was loaded into the PCL microstructure, while TGA analysis showed that the oil increased the thermal stability of the polymeric fibers. SEM showed that the addition of the oil modified fibers structure by reducing the average fiber size from 5.5 μm to 1.7 μm for TO loaded samples. Cell viability assay demonstrated an increment on cell proliferation from 80% of pure PCL to 100% for samples containing TO. Therefore, it can be concluded that tucuma oil can be incorporated into PCL to form fibers by electrospinning, without meaningful changes in its physicochemical properties and increasing its biocompatibility.
Highlights
There are several studies focusing on the manufacture of polymeric fibers and one of the most used processes is electrospinning[1,2,3,4,5,6,7,8]
PCL fibers incorporated with tucuma oil were successfully electrospun and were evaluated with respect to their chemical, physical and morphological properties as well as cytotoxicity
The incorporation of tucuma oil did not affected the PCL chemical structure, which was confirmed by X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR)
Summary
There are several studies focusing on the manufacture of polymeric fibers and one of the most used processes is electrospinning[1,2,3,4,5,6,7,8]. The wide range of commercially available biomaterials, as well as the strategies adopted in tissue engineering and regenerative medicine, favor the search for new products and methodologies to obtain these[15,16,17] In line with this approach, the manufacture of scaffolds from absorbable, hydrolytically degradable polymers belonging to the aliphatic polyester class is being widely investigated for the use in tissue engineering[18,19,20,21,22,23,24]. Their inherent biocompatibility properties and the possibility of undergoing hydrolysis in the body make these biomaterials suitable for the tissue reconstruction process. One can list its ease of processing and modulation of degradation rate, mechanical and visco-elastic properties[25]
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