Abstract
The synthesis of thymidine dimers in which the phosphodiester linkage has been replaced by an amide linkage containing diamines (homopiperazine, 2,5- trans-dimethylpiperazine, N, N-dimethylethylenediamine and N, N-diethylethylenediamine) and their incorporation into oligodeoxynucleotides is described. The thermal and nucleolytic stability of the resulting oligodeoxynucleotide analogues are reported.
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