Incorporation of a β-turn mimic in the N-terminal fragment of the B1 domain of streptococcal protein G

Abstract

A dibenzofuran-based β-turn mimic has been incorporated in the B12–29 fragment of the B1 domain of streptococcal protein G. This amino acid sequence adopts a β-hairpin structure in the complete B1 domain (B12–56). The modified peptide was studied by CD and NMR spectroscopy and its solution behavior was compared with the conformation adopted by the same sequence in the modified B1 domain.