Abstract
In in vivo experiments on rats with experimentally induced hyperaminoacidemia, it was observed that when the plasma concentration of a single amino acid, such as phenylalanine, methionine, histidine or valine was elevated, both the uptake of 14C-leucine by the brain and the incorporation of 14C-leucine into the brain protein were inhibited. These findings suggest that the reduction of brain protein synthesis due to an imbalance of amino acid concentrations in serum may play an important role in the development of the brain damage seen in inbor, errors of amino acid metabolism.
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