Abstract
Abstract - Alpha-bisabolol, an anti-inflammatory and antioxidant compound extracted from candeia trees ( Eremanthus erythropappus ), was incorporated into hydrophobic polycaprolactone (PCL) and hydrophilic chitosan/guar gum (Ch-G) membranes aiming at the production of bioactive wound dressings. The incorporation efficiency achieved a maximum of ca . 18% (1 gram of alpha-bisabolol per gram of membrane) for Ch-G membranes. For PCL membranes, all of the active compound added was retained (0.2 gram of alpha-bisabolol per gram of membrane). Alpha-bisabolol release in phosphate-buffered saline was relatively slow in both cases, reaching around 6% and 24% after 120 hours respectively for PCL and Ch-G membranes presenting equivalent initial alpha-bisabolol/membrane mass ratios. Both formulations were capable of releasing alpha-bisabolol in the typically recommended topical dose range (from 1 to 10 grams of alpha-bisabolol per gram of vehicle). The extended release periods observed are advantageous, allowing less frequent dressing changes and contributing to turn the treatment more comfortable for the patient.
Highlights
The skin is the largest organ of the human body and acts as an interface with the external environment
Wound dressings are used to protect the lesion from mechanical damage and contamination by microorganisms, as well as to provide an appropriate environment for the healing process, which includes the restoration of the epithelium and the formation of collagen (Weller and Sussman, 2006; Mulder et al, 2002)
Before alpha-bisabolol incorporation, chitosan/guar gum (Ch-G) and PCL membranes were exposed to ethanol and to a 25:75 v/v water/ethanol solution to determine their uptake capacity and stability in these solvents
Summary
The skin is the largest organ of the human body and acts as an interface with the external environment. Wound dressings are used to protect the lesion from mechanical damage and contamination by microorganisms, as well as to provide an appropriate environment for the healing process, which includes the restoration of the epithelium and the formation of collagen (Weller and Sussman, 2006; Mulder et al, 2002). They can be classified according to the role they play in the lesion (barrier, debridement, antibacterial, occlusive, absorbent, adherent), the type of material used in its production (hydrocolloid, alginate, collagen, etc.) and their physical form (ointment, film, foam, gel) (Boateng et al, 2008).
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