Abstract
SummaryEndotoxin in concentrations of 5-2500 ng per mg of virus protein, was found in type-C RNA virus reagents. Cell-mediated immune responses induced with these endotoxin-contaminated reagents were evaluated by the lymphocyte transformation assay and the footpad swelling assay. The presence of even subnanogram concentrations of endotoxin altered assay results. Both immunoenhancement and immunosuppression was observed.
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