Abstract
To evaluate renal acidification capacity in sickle cell nephropathy 6 subjects with sickle cell trait (Hb AS), 8 patients with sickle cell hemoglobin C disease (Hb SC), 13 with homozygote sickle cell anemia (Hb SS) and 7 normal controls (Hb AA) were submitted to Wrong and Davies' acidification test. Renal concentrating capacity and glomerular filtration rate were also estimated. Urinary pH after acid loading was significantly higher, titratable acidity (TA) significantly lower in SC and SS patients compared to AS subjects and normals. NH 4 + excretion did not differ between the four groups. In none of the subjects investigated was metabolic acidosis found, characterizing the acidification defect in sickle cell nephropathy as the incomplete form of renal tubular acidosis (RTA). A correlation between the degree of disturbance in renal acidifying and concentrating capacity could be observed.
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