Incomplete or absent acute phase response in some postoperative patients

Abstract

In a prospective study, 74 patients were admitted for an open fracture of the lower limb and treated by osteosynthesis. None of them presented infectious complication during the postoperative period. Among them, 67 exhibited a classical acute phase response. In 5 patients, the response was apparently incomplete since no serum C-reactive protein (CRP) rise was observed after the injury; i.e. CRP concentrations remained inferior to the detection limit of the assay used; in contrast, serum alpha-1 acid glycoprotein (AAG) concentrations were temporarily increased, a variation associated with a concomitant decrease of transthyretin (TTR) concentration. In 2 other patients, CRP and AAG levels were not significantly modified. The 7 patients did not suffer hepatic insufficiency or protein malnutrition. In our series, incomplete or absent acute phase response was not rare (prevalence 9%) and was not related to an increased risk of postoperative infection. In contrast to CRP, the TTR response, i.e. a transitory decrease, was observed in all the 7 patients.