Abstract
In order to examine changes in sodium latamoxef (6059-S; LMOX) due to compounding, it was mixed in solution with each of 26 different commercial replacement fluids and 70 different injections. In addition, changes in the mixed injections containing replacement fluids actually used in wards were examined for stability. Decomposition products were investigated by thin-layer chromatography and bioautography, and the residual potency was determined by the microbiological assay (cylinder-plate method).Aqueous solutions of LMOX were stable in the replacement fluid for 24 hours; however, there were apparent changes in mixed injections containing no replacement fluids, such as Atarax-p, Bisolvon, Cepharanthin, FOY and Horizon. In Neophyllin, the solution showed a decrease in potency with the lapse of time, but was stable in prescriptions of drugs with a replacement fluid, time of 6 hours causing no change in appearance, pH, or potency.
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