Abstract
Botulinum toxin type A is one of the most useful treatments of sialorrhea in neurological disorders. Evidence for the use of incobotulinumtoxin A (inco-A) in the treatment of sialorrhea is limited. Thirty-six patients with sialorrhea were treated with infiltrations of inco-A into both parotid glands. The severity of sialorrhea was evaluated by the Drooling Severity Scale (DSS), and the Drooling Frequency Scale (DFS). Patients’ perceptions of clinical benefit were recorded via the Patient Global Impression of Improvement (PGI-I) scale. Following treatment, there was a significant difference in both the DFS and the DSS (p < 0.001). Clinical benefits on the basis of the PGI-I were present in up to 90% of patients.
Highlights
Sialorrhea is a frequent and disabling symptom of neurological disorders that is present in about10% of patients with chronic neurological disorders, and in nearly 80% of Parkinson’s disease (PD)patients [1,2,3,4]
Thirty-six patients with disabling sialorrhea were included in the study
Dilution was made with 1 mL of saline solution for 100 international units (IU)
Summary
Sialorrhea is a frequent and disabling symptom of neurological disorders that is present in about10% of patients with chronic neurological disorders, and in nearly 80% of Parkinson’s disease (PD)patients [1,2,3,4]. Sialorrhea is a frequent and disabling symptom of neurological disorders that is present in about. 10% of patients with chronic neurological disorders, and in nearly 80% of Parkinson’s disease (PD). The etiology of sialorrhea in patients with neurodegenerative disorders is probably multifactorial. Open-mouth posture, discoordination between oral and pharyngeal stages of swallowing, reduction of spontaneous swallowing, flexed posture, or limited tongue movements can all contribute to disturbances in intraoral saliva management, and sialorrhea [6,7,8]. In PD, there is evidence that the severity of sialorrhea is correlated with dysphagia [7]. Sialorrhea is an important non-motor symptom because it may cause silent aspiration with secondary respiratory infections [9,10], and has a major impact on quality of life [11]
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