Abstract
The methods of obtaining and physicochemical properties of inclusion complexes of amlodipine (AM) and felodipine (FL) with methyl-β-cyclodextrin (MCD) clathrates have been studied. Solid complexes were obtained by two methods: the kneading one and lyophilization with the drug and MCD at the molar ratio of 1:1. The identity of the obtained clathrates was confirmed by IR, 13C-NMR spectra and DSC measurements. The process of AM and FL complexation with MCD was shown to involve the aromatic ring, the carbonyl groups in the ester bonds and the carbon atoms of the DHP ring linked via the ester bonds. One of the aims of complexation was to improve the drug solubility, so the dissolution rate of the obtained clathrates was tested. As a result of the inclusion complexes formation of AM, obtained both by kneading and lyophilization, the solubility of this therapeutic drug increased 3 times. The inclusion complex formation with FL and MCD brought the most dramatic increase in FL solubility, which increased 16 times.
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