Abstract
Molecular tube (MT) consisting of α-cyclodextrins (α-CDs) was prepared, fractionated and characterized in terms of MALDI-TOF mass spectroscopy, isothermal titration calorimetry (ITC), and 1H-NMR titration. MT with various molecular weight (2400–23,000) was separated into seven fractions by gel permeation chromatography and the molecular weight of each MT was determined by MALDI-TOF mass spectroscopy. Furthermore, association constant, stoichiometry and thermodynamic parameters for inclusion complexation of MT with sodium dodecyl sulfate (SDS) were determined by ITC. From the ITC analysis, it was found that inclusion complexation between MT and SDS was enthalpy driven. Further, the association constant was calculated to be the order of 105 M−1. ITC and 1H-NMR titration measurement revealed that one MT molecule (Mn = 7,600, Mw/Mn = 1.41) formed an inclusion complex with two SDS molecules. These results suggest that MT acts as a host molecule with two binding sites at both ends. Therefore, MT is considered to be feasible for constructing various kinds of molecular assemblies. Copyright © 2000 John Wiley & Sons, Ltd.
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