Abstract
The interaction of piroxicam with β-cyclodextrin (β-CD), hexadecyltrimethylammonium bromide-based microemulsion (ME), and ME in the presence of β-CD aimed at the optimization of topical drug delivery was studied. UV–VIS absorption spectra at pH 5.5 were obtained with and without β-CD and ME. The stability constant (K) values for the piroxicam/β-CD complex in the pH range 4.5–6.0 varied from 87 to 29 M −1. The cationic microemulsion was characterized by pseudo-ternary phase diagram. The association constant ( K s) of piroxicam/ME was determined using the framework of the pseudophase model. The value of K s obtained for piroxicam at pH 5.5 was 132 M −1. At the same pH, the value of K s for the incorporation of piroxicam/β-CD complex in the ME was 150 M −1.
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